Featured posts:
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NoSleep for R, Julia, and MATLAB
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Engineering Practices We Can Borrow
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The Missing Link Between Biology and Software Engineering
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For all posts, see Blog page.
About Me
I earned an MSc in Biochemical Physics and a PhD in Biophysics from Lomonosov Moscow State University. Since 2004 I’ve been on a mission to make Quantitative Systems Pharmacology (QSP) modeling as intuitive and scalable as modern software engineering.
Today, as Co‑founder and Technology Director at InSysBio CY Ltd, I drive the creation of next‑generation modeling platforms that empower scientists to iterate, collaborate, and make data‑backed decisions across the drug‑development lifecycle.
What I Do
| Domain |
How I Add Value |
| QSP & PBPK Modeling |
Build and validate large‑scale mechanistic models that translate biology into clinical insight. |
| Data‑Driven Decision Support |
Combine virtual populations, sensitivity analysis and identifiability workflows to quantify uncertainty and derisk R&D. |
| Software Engineering |
Architect cloud‑native simulation engines and domain‑specific languages that scale with model complexity. |
| Infrastructure |
Design and secure global computing infrastructure—from collaboration tooling to HPC cluster that keeps our distributed team productive and data safe. |
| Team Leadership |
Grow and mentor cross‑functional teams of scientists and engineers to ship production‑grade modeling tools. |
Flagship Software Projects
- Heta Language & Heta Compiler — Domain‑specific language + build pipeline for large‑scale QSP models.
- HetaSimulator.jl — Julia‑powered engine for distributed simulations and parameter estimation.
- LikelihoodProfiler.jl — Toolkit for practical identifiability and confidence interval estimation.
- Immune Response Template — Modular QSP platform of the human immune system for fast-model building.
- SbmlViewer — Web apps that turn SBML files into interactive human‑readable forms, enabling easy sharing and collaboration.
Selected Publications & Talks
- LikelihoodProfiler.jl: Unified profile-likelihood workflows for identifiability and confidence intervals. JOSS 11(117), 9501, 2026. DOI: 10.21105/joss.09501.
- Heta compiler: a software tool for the development of large‑scale QSP models and compilation into simulation formats. JOSS 6(67):3708, 2021. DOI: 10.21105/joss.03708.
- Confidence intervals by constrained optimization—An algorithm and software package for practical identifiability analysis in systems biology. PLoS Comput. Biol. 16(12):e1008495, 2020. DOI: 10.1371/journal.pcbi.1008495.
- Comprehensive study of the drug delivery properties of poly( l -lactide)-poly(ethylene glycol) nanoparticles in rats and tumor-bearing mice. J. Control. Release 261, 2017. DOI: 10.1016/j.jconrel.2017.06.006.
- Systems pharmacology perspective on FAAH inhibitors for pain. CPT: Pharmacometrics & Syst. Pharmacol. 3:e91, 2014. DOI: 10.1038/psp.2013.72.
- 60+ additional articles, posters & keynotes → ResearchGate.
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© 2025-2026 Evgeny Metelkin. Opinions expressed are my own and do not necessarily reflect those of InSysBio.
