Evgeny Metelkin, PhD

About Me

I earned an MSc in Biochemical Physics and a PhD in Biophysics from Lomonosov Moscow State University. Since 2004 I’ve been on a mission to make Quantitative Systems Pharmacology (QSP) modeling as intuitive and scalable as modern software engineering.

Today, as Co‑founder and Technology Director at InSysBio CY Ltd, I drive the creation of next‑generation modeling platforms that empower scientists to iterate, collaborate, and make data‑backed decisions across the drug‑development lifecycle.

What I Do

Domain	How I Add Value
QSP & PBPK Modeling	Build and validate large‑scale mechanistic models that translate biology into clinical insight.
Data‑Driven Decision Support	Combine virtual populations, sensitivity analysis and identifiability workflows to quantify uncertainty and derisk R&D.
Software Engineering	Architect cloud‑native simulation engines and domain‑specific languages that scale with model complexity.
Infrastructure	Design and secure global computing infrastructure—from collaboration tooling to HPC cluster that keeps our distributed team productive and data safe.
Team Leadership	Grow and mentor cross‑functional teams of scientists and engineers to ship production‑grade modeling tools.

Posts

Model Formats in Systems Pharmacology. Part 1
The Missing Link Between Biology and Software Engineering
2025-08-22

Flagship Software Projects

Heta Language & Heta Compiler — Domain‑specific language + build pipeline for large‑scale QSP models.
HetaSimulator.jl — Julia‑powered engine for distributed simulations and parameter estimation.
LikelihoodProfiler.jl — Toolkit for practical identifiability and confidence interval estimation.
Immune Response Template — Modular QSP platform of the human immune system for fast-model building.
SbmlViewer — Web apps that turn SBML files into interactive human‑readable forms, enabling easy sharing and collaboration.

Selected Publications & Talks

Heta compiler: a software tool for the development of large‑scale QSP models and compilation into simulation formats. JOSS 6(67):3708, 2021.
Confidence intervals by constrained optimization—An algorithm and software package for practical identifiability analysis in systems biology. PLoS Comput. Biol. 16(12):e1008495, 2020.
Comprehensive study of the drug delivery properties of poly( l -lactide)-poly(ethylene glycol) nanoparticles in rats and tumor-bearing mice. J. Control. Release 261, 2017.
Systems pharmacology perspective on FAAH inhibitors for pain. CPT: Pharmacometrics & Syst. Pharmacol. 3:e91, 2014.
60+ additional articles, posters & keynotes → ResearchGate.

Connect

LinkedIn: linkedin.com/in/metelkin
GitHub: github.com/metelkin
ResearchGate: researchgate.net/profile/Evgeny-Metelkin